and H.S.S. Article  Biochem Biophys Res Commun. Nobuyoshi Shimizu. Positional cloning of the mouse obese gene and its human homologue Nature. Proc.Natl. J. Biol. Genome Res. Google Scholar. eCollection 2020 Oct 20. The mechanisms that balance food intake and energy expenditure determine who will be obese and who will be lean. What if ZF genome turns out to be a dead end? Nature. Metab. J. Clin. Chaplin, T. et al. Lakartidningen. Google Scholar. Blood 86, 2073–2076 (1995). Biochem. et al. Genomics. Correspondence to 2020 Nov 8;21(21):8372. doi: 10.3390/ijms21218372. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. 1995 Mar 9;374(6518):124. doi: 10.1038/374124a0. 225, 608–616 (1996). Genomics 35, 321–327 (1996). Commun. N. Engl. Autoantibodies against aromatic L–amino acid decarboxylase in autoimmune polyendocrine syndrome type I. J. Clin. Endocrinol. How Are Genes Cloned Using Plasmids? West , 2 Pieter de Jong , 2 and Aldons J. Lusis 1 Sci. (2020), Nature Genetics Locating protein-coding regions inhuman DNA sequences by a multiple sensor-neural network approach. Metab., BMC Infectious Diseases Or Biology?! Molecular analysis of a major antigenic region of the 240-kD protein of Mi-2 autoantigen. The Arg257stop (R257X) is the predominant mutation in Finnish APECED patients, accounting for 10/12 alleles studied. eCollection 2020. Google Scholar. Endocrinol. Genet. The identification of the gene defective in APECED should facilitate the genetic diagnosis and potential treatment of the disease and further enhance our general understanding of the mechanisms underlying autoimmune diseases. Ge, Q., Nilasena, D.S., O‘Brien, C.A., Frank, M.B., Targoff, I.N. J. Clin. CAS Article Google Scholar Cloning of rat obese cDNA and its expression in obese rats. Cloning the cDNA of human PWP2, which encodes a protein with WD repeats and maps to 21q22.3. 322, 1829–1836 (1990). Nossal, G.J.V. Authors Y Zhang 1 , R Proenca, M Maffei, M Barone, L Leopold, J M Friedman. The mechanisms that balance food intake and energy expenditure determine who will be obese and who will be lean. Scott, M.S., Chen H., C, Lalioti, M.D .& Antonarakis, S.E. 2020 Sep 30;11:563267. doi: 10.3389/fendo.2020.563267. Invest. Genomic organization and complete nucleotide sequence of the TMEM1 gene on human chromosome 21q22.3. 29, 824–826 (1992).  |  Get time limited or full article access on ReadCube. Lalioti, M.D. 99, 616–623 (1997). J. Clin. Uibo, R. et al 450 enzymes P450scc, P450c17 and P450c21 in autoimmune polyglandular disease types I and II and in isolated Addison's disease. Acad. (2020), Frontiers in Immunology CAS  Med. Front Endocrinol (Lausanne). (3) Positional cloning is an approach by which a disease gene can be cloned by sole information of its physical location on a chromosome. Nature Genet. Nature Genetics USA 88, 11261–11265 (1991). Kentaro Nagamine, Pärt Peterson and Hamish S. Scott: K.N., P.P. Positional cloning information mRNA species / sequence cDNA libraries DNA sequence known or unknown genomic DNA libraries PCR product. Kawasaki, K. et al.  |  Chem. To obtain The molecular basis of the obese mutation in ob2J mice. et al. 6, 747–760 (1996). Clin. Google Scholar. Commun. Genet. Biophys. Find NCBI SARS-CoV-2 literature, sequence, and clinical content: Duvillié B, Kourdoughli R, Druillennec S, Eychène A, Pouponnot C. Front Endocrinol (Lausanne). 271, 29198–29204 (1996). Husebye, E.S. Ahonen, P., Myllarniemi, S., Sipila, I. Coxsackievirus B Type 4 Infection in β Cells Downregulates the Chaperone Prefoldin URI to Induce a MODY4-like Diabetes via. Uberbacher, E.C. eCollection 2020. Scott, H.S. Nagamine, K., Peterson, P., Scott, H. et al. You are using a browser version with limited support for CSS. Affiliation 1 Howard Hughes Medical Institute, Rockefeller University, New York, New York 10021. Internet Explorer). 8, 83–87 (1994). & Bloch, K.D. Plasmids - are tiny circular pieces of DNA that are commonly found in … Arthritis Rheum. J. Hum. ISSN 1546-1718 (online). COVID-19 is an emerging, rapidly evolving situation.