John F. Reardon. 34 , 795–806 (2002) | FAQ, solvent, viscosity decreasing agent, and viscosity controlling. Propylene Glycol Side Effects Redness, Tearing, Itching and Burning. It may cause a variety of mild to moderate side effects in humans. (Propylenecarbonate) Animal testing did not show any effects on fertility. Propylene glycol, an alcohol-based formula, combines with cosmetics and... Irritation, Nausea, Coughing and Wheezing. Learn more | Legal Disclaimer. 18. or cardiovascular, musculoskeletal, dermal, ocular, or metabolic effects in animals after inhalation exposure to propylene glycol. EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. Not … Irritation (skin, eyes, or lungs) (high) solvent, viscosity decreasing agent, and viscosity controlling. All Rights Reserved. It may cause nausea, vomiting and diarrhea if ingested. Thermodyn. Developmental and reproductive toxicity: Ingredients linked to developmental and reproductive toxicity, a broad class of health effects that range from infertility and reproductive organ cancers to birth defects and developmental delays in children. Contact Us | Safety Measures/Side Effects: The Cosmetics Database finds Propylene Glycol to be a moderate hazard ingredient and has concerns regarding cancer, developmental and reproductive toxicity, allergies and immunotoxicity, irritation and enhanced skin absorption, and organ system toxicity. Propylenester Kyseliny Uhlicite [czech], 27. RISK: Moderate skin and eye irritation have been reported in humans with direct contact to concentrated propylene carbonate. 1,3-DIOXOLAN-2-ONE, 4-METHYL-, 1,3DIOXOLAN2ONE, 4METHYL, 4-METHYL- 1,3-DIOXOLAN-2-ONE, 4-METHYL-1,3-DIOXOLAN-2-ONE, CARBONIC ACID CYCLIC METHYLETHYLENE ESTER, and PROPYLENE CARBONATE. Carbonic Acid, Cyclic Propylene Ester, 22. EC (Environment Canada). (Propylene carbonate) (Propylenecarbonate) Specific target organ toxicity - single exposure The substance or mixture is not classified as specific target organ toxicant, single exposure. Carbonic Acid Cyclic Methylethylene Ester, 110. 2008. DOI: 10.1016/S0003-2670(00)85141-7. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Domestic Substances List Categorization. Other data on the potential for propylene carbonate to produce toxic effects in humans were not available. Propylene Carbonate is a clear, odorless solvent with a high boiling point. Allergies and immunotoxicity: Ingredients linked to harm to the immune system, a class of health problems that manifest as allergic reactions or an impaired capacity to fight disease and repair damaged tissue in the body. Lesser concerns include neurotoxicity and endocrine disruption. Know about technical details of Propylene Carbonate like: chemical name, chemistry structure, formulation, uses, toxicity, action, side effects and more at Pharmacompass.com. Cancer: Ingredients linked to cancer in government, industry or academic studies or assessments. 2012. Analytica Chimica Acta 1990, 229, 287-290. Privacy Policy | Classification and Labelling: Chemicals: Annex VI of Directive 67/548/EEC through the 31st ATP. Some probably aren't as safe as you'd hope. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. Copyright © 2020. About SkinDeep®/Methodology the ethylene carbonate–trifluoroethylmethyl carbonate and propylene carbonate–trifluoroethylmethyl carbonate systems at T = (298.15 or 315.15) K. J. Chem. Usually, this makes synthetic chemists think of DMSO, then DMF, then maybe acetonitrile or HMPA. 5-19-04-00021 (beilstein Handbook Reference), InChI=1S/C4H6O3/c1-3-2-6-4(5)7-3/h3H,2H2,1H3, 4-methyl-1,3-dioxolan-2-one, 108-32-7, 1,2-propylene carbonate, 1,3-dioxolan-2-one, 4-methyl-, 1,2-propanediol cyclic carbonate, Texacar pc, Chromatography (TLC / LC / HPLC / UPLC / GC), Complete Pharmacopoeial / Compendial Testing, Bioanalytical & Biomarker Testing Services, Bioequivalence / Clinical / Pre-Clinical Testing, Calculation and Modeling of Pharmacokinetic Parameters, Protein isolation, identification and characterization, Electrical Conductivity / High Voltage Leak Detection (HVLD), Mass Flow / Mass Extraction Leak Detection, European and Japanese Pharmacopoeia (EP & JP) Container Testing, ASTM and ISTA Distribution Simulation Testing, Environmental Conditioning, Cycling and Simulation Testing, Controlled / Immediate / Modified Release, Health / Dietary Supplement (Nutraceutical), Low Temperature / Cryogenic Condition (-78 °C), Pharmacokinetics / Pharmacodynamics / Pharmacometrics, Clinical Research Translation / Validation, Pharmacovigilance / Product Lifecycle Management, High Potent / Biologic / Controlled Substance, Customization (Anodizing, Siliconization, Plastic Coating), Media / Public Relations / Communications, Methacrylic Acid - Ethyl Acrylate Copolymer, Methacrylic Acid Methyl Methacrylate Copolymer, Polyvinyl Alcohol Graft Polyethylene Glycol Copolymer, Betadex Sulfobutyl Ether Sodium Excipient, Hydroxypropyl methylcellulose acetate succinate, Cross Linked Sodium Carboxymethylcellulose, Hepatology (Liver, Pancreatic, Gall Bladder). Washington DC. Did not show teratogenic effects in animal experiments. Canadian Environmental Protection Act (CEPA) Environmental Registry. Propylene carbonate is a synthetic solvent. NLM (National Library of Medicine). 1,3-DIOXOLAN-2-ONE, 4-METHYL-, 1,3DIOXOLAN2ONE, 4METHYL, 4-METHYL- 1,3-DIOXOLAN-2-ONE, 4-METHYL-1,3-DIOXOLAN-2-ONE, CARBONIC ACID CYCLIC METHYLETHYLENE ESTER, and PROPYLENE CARBONATE. Propylene carbonate is a very polar aprotic organic solvent. Environmental Working Group. 2006. Before a company can use EWG VERIFIED™ on such products, the company must show that it fully discloses the products' ingredients on their labels or packaging, they do not contain EWG ingredients of concern, and are made with good manufacturing practices, among other criteria. See that long list of ingredients on the back of the bottle? Propylene glycol is considered “generally” safe by the FDA. 2008. Tacrolimus has an empirical formula of C 44 H 69 NO 12 •H 2 O and a formula weight of 822.03. Note that EWG receives licensing fees from all EWG VERIFIED™ member companies that help to support the important work we do. Build Your Own Report PubMed online scientific bibliography data. Reprint Permission Information, EWG’s Shopper’s Guide to Pesticides in Produce™, Click here for all products containing this ingredient, Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product, 372 studies in PubMed science library may include information on the toxicity of this chemical, Not suspected to be an environmental toxin, Environment Canada Domestic Substance List, Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - any, Classified as not expected to be potentially toxic or harmful. The highest NOAEL values and all reliable LOAEL values for systemic effects in each species and duration category for propylene glycol after inhalation exposure are reported in Table 2-1 and plotted in Fig ure 2-1. | Legal Disclaimer http://www.pubmed.gov. Coulometric generation of H+ ions by anodic oxidation of esters of gallic acid, phenols and ascorbic acid in propylene carbonate. CIR (Cosmetic Ingredient Review). Legal Disclaimer | In cosmetics and personal care products, Propylene Carbonate is used in the formulation of makeup, primarily lipstick, eye shadow, and mascara, as well as in skin cleansing products. Propylene glycol is soluble in water. CPS&Q (Consumer Products Safety & Quality) formely known as ECB (European Chemicals Bureau). Most of the time, propylene glycol does not accumulate in your body, as it breaks down within 48 hours of ingestion or exposure.